Clinical Services
Our Center's focus is the prevention and treatment of Mood Disorders, especially Manic Depressive Illness (MDI), also called bipolar disorder. We advocate and support early detection and prevention of illness' relapses by psychological and pharmacological treatment, while choosing a healthy lifestyle (a balanced diet, sleep hygiene, exercise).
If you are interested in any of the clinical services listed here please call our Clinic at 212-644-3111 or email. We will make every effort to arrange an intake interview as quickly as possible. All treatment is provided by experienced clinicians whose deep knowledge of all issues relating to treatment of Mood Disorders is combined with an empathic and supportive approach. These are some of the sevices we offer:
| Consultation | |
| Diagnostic Evaluation | |
| Semistructured Interviews | |
| Psychopharmacology Consult | |
| Outpatient Follow-up treatment | |
| Actigraphy (Activity Monitoring) | |
| Symptoms' rating scales | |
| Speech and Language, OTR, Educational Assessment | |
| Neuro-psychological testing | |
| Psychological testing | |
| McLean Motion Analysis Testing (MMAT) | |
| Referrals to Specialists (Neurology, Radiology, Endocrinology) |
Self Education
This area is dedicated to patients' self education. To read about MDI, you can access our Articles' Library here or our online book here. Scroll down for a list of conferences and seminars. You can also search articles and topics in the website.
The Clinical Research Program
RESEARCH PROTOCOLS
Our Center's research focus is the Diagnosis, Course and Treatment of Mood Disorders, especially Manic Depressive Illness (MDI), often called Bipolar Disorder. We are interested in the onset, longitudinal course, and response to pharmacological treatments of these Disorders. Your participation is welcome. If you already have an account, please sign-in. We are currently collecting research data from volunteers and/or their parent/guardian.
You (and your child) can choose to be included in any of the following studies:
Pediatric-onset bipolar disorder: a neglected clinical...
Authors: Faedda GL, Baldessarini RJ, Suppes T, Tondo L, Becker I, Lipschitz DS. International Consortium on Bipolar Disorders Research, Albert Einstein College of Medicine, Bronx, N.Y., USA. Harv Rev Psychiatry 1995 Nov-Dec;3(4):171-95
Bipolar disorder (BPD), probably the most prevalent psychotic disorder in adults, has been relatively neglected or controversial in children and adolescents over the past century. We reviewed the literature on early-onset BPD. Estimates of prevalence, particularly before puberty, are limited by historical biases against pediatric mood disorders and by formidable diagnostic complexity and comorbidity. Although clinical features of pediatric and adult BPD have similarities, pediatric cases probably cannot be defined solely by features characteristic of adult cases. Onset was before age 20 years in at least 25% of reported BPD cases, with some increase in this incidence over the past century. Pediatric BPD is familial more often than is adult-onset BPD, may be associated with a premorbid cyclothymic or hyperthymic temperament, and can be precipitated by antidepressant treatment. Pediatric BPD episodes frequently include irritability, dysphoria, or psychotic symptoms; they are commonly chronic and carry high risks of substance abuse and suicide. BPD is often recognized in adolescents, but the syndrome or its antecedents are almost certainly underrecognized and undertreated in children. Controlled studies of short- and long-term treatment, course, and outcome in this disorder remain strikingly limited, and the syndrome urgently requires increased clinical and scientific interest.
Pharmacological treatments
Lithium salts were first reported to be effective in the treatment of Mania by Cade in 1949. Lithium is effective both as an antimanic and as a mood-stabilizing agent.
The use of Lithium as an antimanic agent often requires doses higher than those required for maintenance treatment. Cade's rapid titration has been recently found to be effective in controlling manic symptoms among inpatients with Mania.
The MoodLog
The MoodLog is a data management system for patients with Bipolar Disorder, also known as Manic Depressive Illness.
The method of collecting information longitudinally in mood disorders dates back to the end of 1800. Charts, or Mood charts and diaries were used to track symptoms longitudinally. This method is consistently the most reliable and efficient way of monitoring BD over time.
The 'Lucio Bini' Center of New York
The 'Lucio Bini' Center of New York was founded in 1991 by Dr. Gianni Faedda, its current Director.
The 'Lucio Bini' Center of Rome was founded by Dr. Athanasios Koukopoulos in 1975.
The 'Lucio Bini' Center of Cagliari was founded in 1977 by Dr. Leonardo Tondo, the current Director, and is now a Stanley Foundation International Research Center.
The Centers are named after Prof. Lucio Bini (Rome 1908-1964), Dr. Koukopoulos' mentor.
Profs. Bini and Cerletti, former Chairman of the Deparment of Neurology and Psychiatry at the University of Rome, discovered the efficacy of Electroconvulsive therapy (ECT) in 1938 and were nominated for the Nobel Prize.
The three Centers are independent associations of Psychiatrists, Psychologists and other mental health professionals dedicated to the 'prevention and treatment of Depression, Mood and Anxiety Disorders'.
Welcome Message
Welcome to the 'Lucio Bini' Mood Disorders Center in New York City. The Center's New York branch is located on 50th Street in midtown Manhattan. This center was founded and is directed by a psychiatrist, Dr. Gianni Faedda. Dr. Nancy Austin a psychologist, is the Associate Director. In collaboration with affiliated professionals in different disciplines, we provide comprehensive Evaluation and Treatment for Mood and Anxiety Disorders to patients of all ages.
The Center provides Clinical Services for children, adolescents and adults.
We offers follow-up treatment, combining psychopharmacology with individual, group and family psychotherapy, offering support and education to patients and their families. The Center conducts independent and collaborative Research, and is active in public and professional Education.
The Pharmacological Treatment of Pediatric BD
Bipolar Disorder in Children and Adolescents
by Gianni L. Faedda, MD
In Press, the Interdevelopmental Council of Developmental and Learning Disorders; presented at the 2003 Annual Conference DC, November 2003
Pharmacotherapy is often, if not always, the foundation for the successful treatment of Bipolar Disorder in any age group. However, non-compliance with treatment often interferes with successful outcome.
Pharmacological treatment should always be considered part of a comprehensive therapeutic approach. This requires addressing issues pertaining to lifestyle (sleep hygiene, exercise, diet, socialization) as well as school interventions (addressing learning disabilities and problems with executive functioning), and psychoeducation.
Dr. Faedda's Biographical Sketch
Gianni L. Faedda, MD
Education
MD: University of Cagliari Medical School, Italy
Residency: Harvard Medical School/McLean Hospital, Belmont MA
Fellowship (Neuropharmacology): Harvard Medical School/McLean Hospital, Belmont MA
Fellowship (Clinical Psychopharmacology): Albert Einstein College of Medicine, Bronx, New York
Board Certification
American Board of Neurology and Psychiatry (Psychiatry)
Dr. Faedda is a psychopharmacologist with extensive expertise in the maintenance treatment of patients with mood and anxiety disorders. He maintains an active clinical practice within the Mood Disorders Center, seeing patients with a wide range of psychiatric disorders. In addition to patients with Bipolar Disorder, Dr. Faedda has a special interest in patients with early onset of mood, attention and anxiety disorders, including such conditions as Attention Deficit Disorders (ADD and ADHD), depression, separation anxiety, phobias, OCD and PTSD, and their interplay with Learning Disabilities or Sensory disregulation. Dr. Faedda often consults on patients with refractory mood disorders, a history of treatment failure or adverse reactions.
In addition to his clinical work, Dr. Faedda is engaged in academic pursuits within Psychiatry. He reviews manuscripts for the journals Bipolar Disorder, Essential Psychopharmacology, CNS Spectrum, Journal of Affective Disorders and the Journal of Bipolar Disorders and has authored 40 peer-reviewed articles. Dr. Faedda is a member of the American Psychiatric Association since 1988 and a Lifetime Member of the International Society for Bipolar Disorder, and co-chair, Governance Committee. He supervises psychology graduate students during their internships and internships, as well as their fellowship-training at the Mood Disorders Center. He has written and published extensively and lectures nationally and internationally on the topic of mood disorders.
Consultation
Before we schedule an appointment for a consultation, we need to obtain some basic information. Please follow these three steps:
1- Complete the Registration form to receive your ID number
2- Complete the Child version or the Adult version of the Enrollment form.
3- When finished, please Contact us with your ID number
Treatment-emergent mania in pediatric bipolar disorder
Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB.
Journal of Affective Disorders 2004 Oct 1;82(1):149-58.
Background: Pediatric bipolar disorder (BPD) can be misdiagnosed as a depressive, attention, conduct, or anxiety disorder and treatment with antidepressants and stimulants is common. Risk of adverse outcomes related to such treatment remains poorly defined.
Methods: We analyzed clinical records of 82 children (mean age 10.6 years) meeting modified DSM-IV diagnostic criteria for BPD to evaluate risk and timing of operationally-defined treatment-emergent mania (TEM) or increased mood-cycling following pharmacological treatment.
Phenomenology and Course of Pediatric Bipolar Disorder
Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB.
Bipolar Disorder 2004: 6: 305–313.
Background: Specific features and diagnostic boundaries of childhood
bipolar disorder (BD) remain controversial, and its differentiation from
other disorders challenging, owing to high comorbidity with other
common childhood disorders, and frequent lack of an episodic course
typical of adult BD.
Methods: We repeatedly examined children meeting DSM-IV criteria
for BD (excluding episode-duration requirements) and analyzed their
clinical records to evaluate age-at-onset, family history, symptoms,
course, and comorbidity.
Results: Of 82 juveniles (aged 10.6 ± 3.6 years) diagnosed with BD,
90% had a family history of mood or substance-use disorders, but only
10% of patients had been diagnosed with BD. In 74%, psychopathology
was recognized before age 3, usually as mood and sleep disturbances,
hyperactivity, aggression, and anxiety. At onset, dysphoric-manic and
mixed presentations were most common (48%), euphoric mania less
(35%), and depression least (17%). Subtype diagnoses were: BP-I
(52%) > BP-II (40%) > cyclothymia (7%). DSM episode-duration
criteria were met in 52% of cases, and frequent shifts of mood and energy
"Fifth International Conference on Bipolar Disorder"
June 12 - 14, 2003
Sheraton Hotel at Station Square
Pittsburgh, Pennsylvania, USA
The poster entitled Phenomenology and Course of Pediatric Bipolar Disorder will be displayed in conjunction with a reception on Thursday evening, June 12, 2003 from 4:30 p.m. to 6:00 p.m.
The poster entitled Treatment-emergent Mania in Pediatric Bipolar Disorder will be displayed on Friday evening, June 13, 2003 from 4:30 p.m. to 6:00 p.m.
"THE BIPOLAR SPECTRUM: ROOTS AND WINGS"
"THE BIPOLAR SPECTRUM: ROOTS AND WINGS"
“LO SPETTRO BIPOLARE: LE RADICI E LE ALI”
Roma, 5-6 Maggio 2003
Residenza di Ripetta
Via di Ripetta 231
Informed Consent - Child version
INFORMED CONSENT FOR PARTICIPATION IN RESEARCH
Before allowing participation in any research study, we require that a document called the Informed Consent (IC) - Child be completed.
The Informed Consent has to be read and clearly understood. An original IC form must be printed, signed and mailed to the Center's address.
Informed Consent - Adult version
INFORMED CONSENT FOR PARTICIPATION IN RESEARCH
Before allowing participation in any research study, we require that a document called the Informed Consent (IC) - Adult be completed.
The Informed Consent has to be read and clearly understood. An original IC form must be printed, signed and mailed to the Center's address.
Risks of interrupting maintenance therapy with psychotropic medi
Risks of interrupting maintenance therapy
Authors: Baldessarini RJ, Suppes T, Tondo L, Faedda GL, Viguera A, Tohen M.
Dir Psychiatry, 1995; Vol. 15:2-7
Comorbidity in psychosis at first hospitalization
Comorbidity in psychosis at first hospitalization.
Authors: Strakowski SM, Tohen M, Stoll AL, Faedda GL, Mayer PV, Kolbrener ML, Goodwin DC.
Epidemiology Laboratory, McLean Hospital, Belmont, Mass.
Am J Psychiatry 1993 May;150(5):752-7
Possible affective-state dependence of the TPQ
Possible affective-state dependence of the Tridimensional Personality Questionaire
in first-episode psychosis.
Authors: Strakowski SM, Faedda GL, Tohen M, Goodwin DC, Stoll AL.
Psychiatry Research, 1992; 41:215-226
Episode Sequence in Bipolar Disorder and Response to Lithium...
Episode Sequence in Bipolar Disorder and Response to Lithium Treatment.
Authors: Faedda GL, Baldessarini RJ, Tohen M, Strakowski SM, Waternaux C.
Am J Psychiatry, 1991; 148:1237-1239
Lithium discontinuation: uncovering latent bipolar disorder?
Lithium discontinuation: uncovering latent bipolar disorder?
Authors: Faedda GL, Tondo L, Baldessarini RJ.
Lucio Bini Center, New York NY 10023; Department of Psychiatry, Harvard Medical School; and the International Consortium for Bipolar Disorder Research.
Am J Psychiatry. 2001 Aug;158(8):1337-9
Seasonal mood disorders. Patterns of seasonal recurrence...
Seasonal mood disorders. Patterns of seasonal recurrence in mania and depression.
Authors: Faedda GL, Tondo L, Teicher MH, Baldessarini RJ, Gelbard HA, Floris GF.
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Mass.
Arch Gen Psychiatry 1993 Jan;50(1):17-23
Outcome after rapid vs gradual discontinuation of lithium...
Outcome after rapid vs. gradual discontinuation of lithium treatment in bipolar disorders.
Authors: Faedda GL, Tondo L, Baldessarini RJ, Suppes T, Tohen M.
Department of Psychiatry, Harvard Medical School, Boston, Mass.
Arch Gen Psychiatry 1993 Jun;50(6):448-55
The Tridimensional Personality Questionnaire...
The Tridimensional Personality Questionnaire as a predictor of six-month outcome in first episode mania.
Authors: Strakowski SM, Stoll AL, Tohen M, Faedda GL, Goodwin DC.
Division of Psychotic Disorders Research, University of Cincinnati College of Medicine, OH 45267-0559.
Psychiatry Res 1993 Jul;48(1):1-8
Correlates of violence risk in hospitalized adolescents
Correlates of violence risk in hospitalized adolescents.
Authors: Grosz DE, Lipschitz DS, Eldar S, Finkelstein G, Blackwood N, Gerbino-Rosen G, Faedda GL, Plutchik R.
Division of Child and Adolescent Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Compr Psychiatry 1994 Jul-Aug;35(4):296-300
Prevalence and characteristics of physical and sexual abuse...
Prevalence and characteristics of physical and sexual abuse among psychiatric outpatients.
Authors: Lipschitz DS, Kaplan ML, Sorkenn JB, Faedda GL, Chorney P, Asnis GM.
Yale University School of Medicine, Connecticut, USA.
Psychiatr Serv 1996 Feb;47(2):189-91
Effects of the rate of discontinuing lithium maintenance treatme
Effects of the rate of discontinuing lithium maintenance treatment in bipolar disorders.
Authors: Baldessarini RJ, Tondo L, Faedda GL, Suppes TR, Floris G, Rudas N.
Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mass, USA.
J Clin Psychiatry 1996 Oct;57(10):441-8
Association of codon 108/158 catechol-O-methyltransferase...
Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.
Authors: Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF.
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Am J Med Genet 1996 Sep 20;67(5):468-72
Molecular analysis of velo-cardio-facial syndrome patients...
Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders.
Authors: Carlson C, Papolos D, Pandita RK, Faedda GL, Veit S, Goldberg R, Shprintzen R, Kucherlapati R, Morrow B.
Department of Molecular Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.
Am J Hum Genet 1997 Apr;60(4):851-9