Self-Education
Self Education
This area is dedicated to patients' self education. To read about MDI, you can access our Articles' Library here or our online book here. Scroll down for a list of conferences and seminars. You can also search articles and topics in the website.
Pediatric-onset bipolar disorder: a neglected clinical...
Authors: Faedda GL, Baldessarini RJ, Suppes T, Tondo L, Becker I, Lipschitz DS. International Consortium on Bipolar Disorders Research, Albert Einstein College of Medicine, Bronx, N.Y., USA. Harv Rev Psychiatry 1995 Nov-Dec;3(4):171-95
Bipolar disorder (BPD), probably the most prevalent psychotic disorder in adults, has been relatively neglected or controversial in children and adolescents over the past century. We reviewed the literature on early-onset BPD. Estimates of prevalence, particularly before puberty, are limited by historical biases against pediatric mood disorders and by formidable diagnostic complexity and comorbidity. Although clinical features of pediatric and adult BPD have similarities, pediatric cases probably cannot be defined solely by features characteristic of adult cases. Onset was before age 20 years in at least 25% of reported BPD cases, with some increase in this incidence over the past century. Pediatric BPD is familial more often than is adult-onset BPD, may be associated with a premorbid cyclothymic or hyperthymic temperament, and can be precipitated by antidepressant treatment. Pediatric BPD episodes frequently include irritability, dysphoria, or psychotic symptoms; they are commonly chronic and carry high risks of substance abuse and suicide. BPD is often recognized in adolescents, but the syndrome or its antecedents are almost certainly underrecognized and undertreated in children. Controlled studies of short- and long-term treatment, course, and outcome in this disorder remain strikingly limited, and the syndrome urgently requires increased clinical and scientific interest.
The Pharmacological Treatment of Pediatric BD
Bipolar Disorder in Children and Adolescents
by Gianni L. Faedda, MD
In Press, the Interdevelopmental Council of Developmental and Learning Disorders; presented at the 2003 Annual Conference DC, November 2003
Pharmacotherapy is often, if not always, the foundation for the successful treatment of Bipolar Disorder in any age group. However, non-compliance with treatment often interferes with successful outcome.
Pharmacological treatment should always be considered part of a comprehensive therapeutic approach. This requires addressing issues pertaining to lifestyle (sleep hygiene, exercise, diet, socialization) as well as school interventions (addressing learning disabilities and problems with executive functioning), and psychoeducation.
New Technologies for the Assessment of ADHD
"New York, NY
May 4, 2004"
"ISSUE WORKSHOP 47
9:00 a.m.-10:30 a.m.
Booth/Edison Rooms, Fifth Floor, Marriott Marquis
Co-Chps.: Martin H. Teicher, M.D., Gianni L. Faedda, M.D.
Participants: Carl M. Anderson, Ph.D., F. Xavier Castellanos, M.D.
Bipolar Disorder at the 92nd Street Y
"The 92nd Street Y"
A Panel Discussion with
Drs. Kay Jamison, Bruce Cohen and Gianni Faedda.
Welcome to the Library
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Manic Depressive Illness
Information on the following topics is available in our online book
- Symptoms
- Misdiagnosis
- Dysthymia
- Differential Diagnosis of Mania
- Differential Diagnosis of Depression
Treatment-emergent mania in pediatric bipolar disorder
Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB.
Journal of Affective Disorders 2004 Oct 1;82(1):149-58.
Background: Pediatric bipolar disorder (BPD) can be misdiagnosed as a depressive, attention, conduct, or anxiety disorder and treatment with antidepressants and stimulants is common. Risk of adverse outcomes related to such treatment remains poorly defined.
Methods: We analyzed clinical records of 82 children (mean age 10.6 years) meeting modified DSM-IV diagnostic criteria for BPD to evaluate risk and timing of operationally-defined treatment-emergent mania (TEM) or increased mood-cycling following pharmacological treatment.
Phenomenology and Course of Pediatric Bipolar Disorder
Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB.
Bipolar Disorder 2004: 6: 305–313.
Background: Specific features and diagnostic boundaries of childhood
bipolar disorder (BD) remain controversial, and its differentiation from
other disorders challenging, owing to high comorbidity with other
common childhood disorders, and frequent lack of an episodic course
typical of adult BD.
Methods: We repeatedly examined children meeting DSM-IV criteria
for BD (excluding episode-duration requirements) and analyzed their
clinical records to evaluate age-at-onset, family history, symptoms,
course, and comorbidity.
Results: Of 82 juveniles (aged 10.6 ± 3.6 years) diagnosed with BD,
90% had a family history of mood or substance-use disorders, but only
10% of patients had been diagnosed with BD. In 74%, psychopathology
was recognized before age 3, usually as mood and sleep disturbances,
hyperactivity, aggression, and anxiety. At onset, dysphoric-manic and
mixed presentations were most common (48%), euphoric mania less
(35%), and depression least (17%). Subtype diagnoses were: BP-I
(52%) > BP-II (40%) > cyclothymia (7%). DSM episode-duration
criteria were met in 52% of cases, and frequent shifts of mood and energy
"Fifth International Conference on Bipolar Disorder"
June 12 - 14, 2003
Sheraton Hotel at Station Square
Pittsburgh, Pennsylvania, USA
The poster entitled Phenomenology and Course of Pediatric Bipolar Disorder will be displayed in conjunction with a reception on Thursday evening, June 12, 2003 from 4:30 p.m. to 6:00 p.m.
The poster entitled Treatment-emergent Mania in Pediatric Bipolar Disorder will be displayed on Friday evening, June 13, 2003 from 4:30 p.m. to 6:00 p.m.
Bipolar Children and Adolescents: Effective Treatment Options
American Psychological Association, Toronto, August 8-10, 2003
Metro Toronto Convention Centre, Meeting Room 206F
August 8th, 9:00 am
Nancy B. Austin, PsyD, Gianni L. Faedda, MD, Ira P. Glovinsky, PhD
Agitated Depression as a mixed state
Agitated Depression as a mixed state and the problem of melancholia
Authors: Koukopoulos At, Koukopoulos Al
Psychiatr Clin North Am - 01-Sep-1999; 22(3): 547-64
"THE BIPOLAR SPECTRUM: ROOTS AND WINGS"
"THE BIPOLAR SPECTRUM: ROOTS AND WINGS"
“LO SPETTRO BIPOLARE: LE RADICI E LE ALI”
Roma, 5-6 Maggio 2003
Residenza di Ripetta
Via di Ripetta 231
Risks of interrupting maintenance therapy with psychotropic medi
Risks of interrupting maintenance therapy
Authors: Baldessarini RJ, Suppes T, Tondo L, Faedda GL, Viguera A, Tohen M.
Dir Psychiatry, 1995; Vol. 15:2-7
Comorbidity in psychosis at first hospitalization
Comorbidity in psychosis at first hospitalization.
Authors: Strakowski SM, Tohen M, Stoll AL, Faedda GL, Mayer PV, Kolbrener ML, Goodwin DC.
Epidemiology Laboratory, McLean Hospital, Belmont, Mass.
Am J Psychiatry 1993 May;150(5):752-7
Possible affective-state dependence of the TPQ
Possible affective-state dependence of the Tridimensional Personality Questionaire
in first-episode psychosis.
Authors: Strakowski SM, Faedda GL, Tohen M, Goodwin DC, Stoll AL.
Psychiatry Research, 1992; 41:215-226
Episode Sequence in Bipolar Disorder and Response to Lithium...
Episode Sequence in Bipolar Disorder and Response to Lithium Treatment.
Authors: Faedda GL, Baldessarini RJ, Tohen M, Strakowski SM, Waternaux C.
Am J Psychiatry, 1991; 148:1237-1239
Lithium discontinuation: uncovering latent bipolar disorder?
Lithium discontinuation: uncovering latent bipolar disorder?
Authors: Faedda GL, Tondo L, Baldessarini RJ.
Lucio Bini Center, New York NY 10023; Department of Psychiatry, Harvard Medical School; and the International Consortium for Bipolar Disorder Research.
Am J Psychiatry. 2001 Aug;158(8):1337-9
Seasonal mood disorders. Patterns of seasonal recurrence...
Seasonal mood disorders. Patterns of seasonal recurrence in mania and depression.
Authors: Faedda GL, Tondo L, Teicher MH, Baldessarini RJ, Gelbard HA, Floris GF.
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Mass.
Arch Gen Psychiatry 1993 Jan;50(1):17-23
Outcome after rapid vs gradual discontinuation of lithium...
Outcome after rapid vs. gradual discontinuation of lithium treatment in bipolar disorders.
Authors: Faedda GL, Tondo L, Baldessarini RJ, Suppes T, Tohen M.
Department of Psychiatry, Harvard Medical School, Boston, Mass.
Arch Gen Psychiatry 1993 Jun;50(6):448-55
The Tridimensional Personality Questionnaire...
The Tridimensional Personality Questionnaire as a predictor of six-month outcome in first episode mania.
Authors: Strakowski SM, Stoll AL, Tohen M, Faedda GL, Goodwin DC.
Division of Psychotic Disorders Research, University of Cincinnati College of Medicine, OH 45267-0559.
Psychiatry Res 1993 Jul;48(1):1-8
Correlates of violence risk in hospitalized adolescents
Correlates of violence risk in hospitalized adolescents.
Authors: Grosz DE, Lipschitz DS, Eldar S, Finkelstein G, Blackwood N, Gerbino-Rosen G, Faedda GL, Plutchik R.
Division of Child and Adolescent Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Compr Psychiatry 1994 Jul-Aug;35(4):296-300
Prevalence and characteristics of physical and sexual abuse...
Prevalence and characteristics of physical and sexual abuse among psychiatric outpatients.
Authors: Lipschitz DS, Kaplan ML, Sorkenn JB, Faedda GL, Chorney P, Asnis GM.
Yale University School of Medicine, Connecticut, USA.
Psychiatr Serv 1996 Feb;47(2):189-91
Effects of the rate of discontinuing lithium maintenance treatme
Effects of the rate of discontinuing lithium maintenance treatment in bipolar disorders.
Authors: Baldessarini RJ, Tondo L, Faedda GL, Suppes TR, Floris G, Rudas N.
Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mass, USA.
J Clin Psychiatry 1996 Oct;57(10):441-8
Association of codon 108/158 catechol-O-methyltransferase...
Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.
Authors: Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF.
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Am J Med Genet 1996 Sep 20;67(5):468-72
Molecular analysis of velo-cardio-facial syndrome patients...
Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders.
Authors: Carlson C, Papolos D, Pandita RK, Faedda GL, Veit S, Goldberg R, Shprintzen R, Kucherlapati R, Morrow B.
Department of Molecular Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.
Am J Hum Genet 1997 Apr;60(4):851-9
Discontinuation of maintenance treatment in bipolar disorder...
Discontinuation of maintenance treatment in bipolar disorder: risks and implications.
Authors: Suppes T, Baldessarini RJ, Faedda GL, Tondo L, Tohen M.
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Mass., USA.
Harv Rev Psychiatry 1993 Sep-Oct;1(3):131-44
Risk of recurrence following discontinuation of lithium...
Risk of recurrence following discontinuation of lithium treatment in bipolar disorder.
Authors: Suppes T, Baldessarini RJ, Faedda GL, Tohen M.
Department of Psychiatry, Harvard Medical School, Boston, Mass.
Arch Gen Psychiatry 1991 Dec;48(12):1082-8
A Mixed depressive syndrome
A Mixed depressive syndrome
Authors: Koukopoulos A, Faedda G, Proietti R, D'Amico S, de Pisa E, Simonetto C.
Lucio Bini Center, Rome, Italy
Encephale 1992 Jan;18 Spec No 1:19-21
The McLean First-Episode Psychosis Project: six-month...
The McLean First-Episode Psychosis Project: six-month recovery and recurrence outcome.
Authors:Tohen M, Stoll AL, Strakowski SM, Faedda GL, Mayer PV, Goodwin DC, Kolbrener ML, Madigan AM.
McLean Hospital, Belmont, MA 02178.
Schizophr Bull 1992;18(2):273-82